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Whole Chromosome Probes and Spectral Karyotyping in the FISH Probe Market
Description: This article examines the function and utility of Whole Chromosome Probes (WCPs) and related multicolor techniques like M-FISH in complex chromosomal analysis.
Whole Chromosome Probes (WCPs) represent a specialized segment within the Fluorescence In Situ Hybridization Probe Market, utilized for global visualization of chromosomal structure. A WCP is a collection of smaller probes that together cover the entire length of a single, specific chromosome. When applied, this "paint" visually tags the entire chromosome with a distinct fluorescent color, enabling its clear distinction from all others in the cell nucleus.
The main application of WCPs is in the analysis of complex chromosomal rearrangements, particularly in cancer and unexplained developmental delays. They are indispensable for identifying the origin of marker chromosomes or characterizing complex translocations where a piece of one chromosome has moved to another. By painting the chromosomes, WCPs allow…